A Phase 2/3 Study of Osivelotor in Sickle Cell Disease

Study Description

A Study to Evaluate the Safety and Effectiveness of a New Drug Called Osivelotor in People with Sickle Cell Disease

Study Details

Registry ID:

NCT05431088

Conditions:

Sickle Cell Disease

Phase:

Phase 2,Phase 3

Target Enrollment:

389 participants

Start Date:

September 22, 2022

Age Range:

12–999 years

Healthy Volunteers:

No

Study Locations (68 sites)

• Lagos University Teaching Hospital Haematology
  Idi Araba, LagosNigeria, Nigeria
• Lagos University Teaching Hospital
  LagosNigeria, Nigeria
• University College Hospital Ibadan
  Ibadan, Oyo/ibadan NorthNigeria, Nigeria
• University College Hospital
  OyoNigeria, Nigeria
• Aminu Kano Teaching Hospital
  KanoNigeria, Nigeria
• KEMRI/CRDR, Siaya, KEMRI Clinical Research Annex
  Kisumu, Siaya CountyKenya, Kenya
• KEMRI/CRDR, Siaya, KEMRI Clinical Research Annex
  Kisumu, SiayaKenya, Kenya
• Multihemo Servicos Medicos S/A
  Recife, PEBrazil, Brazil
• Multihemo Servicos Medicos S/A
  Recife, PernambucoBrazil, Brazil
• Gertrude's Children's Hospital
  NairobiKenya, Kenya
• Kenya Medical Research Institute - Centre for Respiratory Disease Research
  NairobiKenya, Kenya
• Center for Research In Therapeutic Sciences (CREATES), Strathmore University Medical Centre
  NairobiKenya, Kenya
• Hospital Universitario Professor Edgar Santos
  Salvador, Estado de BahiaBrazil, Brazil
• Hospital Universitario Professor Edgar Santos
  Salvador, BahiaBrazil, Brazil
• Instituto Estadual de Hematologia Arthur Siqueira Cavalcanti - HEMORIO
  Rio de JaneiroBrazil, Brazil
• HEMORIO - Unidade de Pesquisa Clínica
  Rio De JaneiroBrazil, Brazil
• Nini Hospital s.a:l
  TripoliLebanon, Lebanon
• University Hospitals Bristol and Weston NHS Foundation Trust
  BristolUnited Kingdom, United Kingdom
• Bristol Royal Infirmary
  BristolUnited Kingdom, United Kingdom
• Esho Empresa De Servicos Hospitalares S.A/ Hospital Samaritano Higienopolis
  Sao PauloBrazil, Brazil
• Real e Benemerita Associacao Portuguesa de Sao Paulo
  Sao PauloBrazil, Brazil
• Casa de Saude Santa Marcelina
  São Paulo, São PauloBrazil, Brazil
• Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
  São PauloBrazil, Brazil
• BP A Beneficência Portuguesa de São Paulo
  São Paulo, São PauloBrazil, Brazil
• Esho Empresa de Servicos Hospitalares S A
  São Paulo, SÃO Paulo- BrasilBrazil, Brazil
• Hospital Das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP
  Ribeirão Preto, SÃO PauloBrazil, Brazil
• Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
  São José Do Rio Preto, SÃO PauloBrazil, Brazil
• Nirmal Hospital Pvt Ltd
  Surat, GujaratIndia, India
• Chopda Medicare & Research Centre Pvt. Ltd: Magnum Heart Institute
  Nashik, MaharashtraIndia, India
• Smilow Cancer Center at Yale New Haven Hospital
  New Haven, ConnecticutUnited States, United States
• Smilow Cancer Hospital
  New Haven, ConnecticutUnited States, United States
• Edward Jenner Research Group LLC.
  Miami, FloridaUnited States, United States
• Edward Jenner Research Group, LLC
  Plantation, FloridaUnited States, United States
• Palm Beach Children's Hospital
  West Palm Beach, FloridaUnited States, United States
• St. Mary's Medical Center
  West Palm Beach, FloridaUnited States, United States
• Palm Beach Children's Hospital at St. Mary's Medical Center
  West Palm Beach, FloridaUnited States, United States
• Pediatric Hematology / Oncology a division of Kidz Medical services
  West Palm Beach, FloridaUnited States, United States
• Virginia Commonwealth University- Clinical Research Services Unit
  Richmond, VirginiaUnited States, United States
• Clinical Research Services Unit - Virginia Commonwealth University Medical Center
  Richmond, VirginiaUnited States, United States
• Children's National Hospital
  Washington D.C., District of ColumbiaUnited States, United States
• Children's National Hospital
  Washington, District of ColumbiaUnited States, United States
• Inova Center for Personalized Health
  Fairfax, VirginiaUnited States, United States
• Inova Schar Cancer Institute
  Fairfax, VirginiaUnited States, United States
• UNC IDS
  Morrisville, North CarolinaUnited States, United States
• UNC Eastowne Medical Office Building - Consent Only
  Chapel Hill, North CarolinaUnited States, United States
• Clinical & Translational Research Center (CTRC)
  Chapel Hill, North CarolinaUnited States, United States
• UNC Hospitals, The University of North Carolina at Chapel Hill
  Chapel Hill, North CarolinaUnited States, United States
• UNC Health
  Chapel Hill, North CarolinaUnited States, United States
• Sonar Clinical Research
  Riverdale, GeorgiaUnited States, United States
• Sonar Clinical Research
  Atlanta, GeorgiaUnited States, United States
• Alpha Clinical Research of Georgia LLC
  Atlanta, GeorgiaUnited States, United States
• Alpha Clinical Research Georgia
  Dunwoody, GeorgiaUnited States, United States
• University Medical Center, New Orleans
  New Orleans, LouisianaUnited States, United States
• Mississippi Center for Advanced Medicine
  Madison, MississippiUnited States, United States
• Our lady of the Lake Hospital
  Baton Rouge, LouisianaUnited States, United States
• LSU Health Baton Rouge-North Clinic
  Baton Rouge, LouisianaUnited States, United States
• Our Lady of the Lake Regional Medical Center
  Baton Rouge, LouisianaUnited States, United States
• University of Illinois at Chicago Clinical Research Center
  Chicago, IllinoisUnited States, United States
• Lynn Institute of the Ozarks
  Little Rock, ArkansasUnited States, United States
• The University of Texas Health Science Center at Houston
  Houston, TexasUnited States, United States
• Memorial Hermann Hospital, Texas Medical Center - Clinical Research Unit (CRU)
  Houston, TexasUnited States, United States
• McGovern Medical School/Health Science Center Houston
  Houston, TexasUnited States, United States
• McGovern Medical School at UTHealth
  Houston, TexasUnited States, United States
• UT Physicians Comprehensive Sickle Cell Clinic
  Houston, TexasUnited States, United States
• Truman Medical Center
  Kansas City, MissouriUnited States, United States
• University Health
  Kansas City, MissouriUnited States, United States
• Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center
  Torrance, CaliforniaUnited States, United States
• AMR Clinical - Mobile
  Mobile, AlabamaUnited States, United States

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