A Phase 2 study of MTX-474 in diffuse cutaneous systemic sclerosis

Study Description

A study testing whether MTX-474, a new investigational medicine given by IV infusion, is safe and effective for treating diffuse cutaneous systemic sclerosis (a form of scleroderma)

Study Details

Registry ID:

NCT07287670

Conditions:

Diffuse Cutaneous Systemic Sclerosis

Phase:

Phase 2

Target Enrollment:

85 participants

Start Date:

April 16, 2026

Age Range:

18–999 years

Healthy Volunteers:

No

Study Locations (63 sites)

• EncompaSSc site in Malaga, Spain
  MálagaSpain, Spain
• EncompaSSc site in Córdoba, Spain
  CórdobaSpain, Spain
• EncompaSSc site in Valencia, Spain
  ValenciaSpain, Spain
• EncompaSSc site in Catania, Italy
  CataniaItaly, Italy
• EncompaSSc site in Barcelona, Spain
  BarcelonaSpain, Spain
• EncompaSSc site in Toulouse, France
  ToulouseFrance, France
• EncompaSSc site in Montpellier, France
  MontpellierFrance, France
• EncompaSSc site in Genoa, Italy
  GenoaItaly, Italy
• EncompaSSc site in La Tronche, France
  La TroncheFrance, France
• EncompaSSc site in Ancona, Italy
  AnconaItaly, Italy
• EncompaSSc site in Modena, Italy
  ModenaItaly, Italy
• EncompaSSc site in Roma, Italy
  RomaItaly, Italy
• EncompaSSc site in Milan, Italy
  MilanItaly, Italy
• EncompaSSc site in Paris, France
  ParisFrance, France
• EncompaSSc site in Vandœuvre-lès-Nancy, France
  Vandœuvre-lès-NancyFrance, France
• EncompaSSc site in Strasbourg, France
  StrasbourgFrance, France
• EncompaSSc site in Timişoara, Romania
  TimișoaraRomania, Romania
• EncompaSSc site in London, UK
  LondonUnited Kingdom, United Kingdom
• EncompaSSc site in Bucharest, Romania
  BucharestRomania, Romania
• EncompaSSc site in Westcliff-on-Sea, UK
  Westcliff-on-SeaUnited Kingdom, United Kingdom
• EncompaSSc site in Brasov, Romania
  BrasovRomania, Romania
• EncompaSSc site in Walsgrave Coventry, UK
  CoventryUnited Kingdom, United Kingdom
• EncompaSSc site in Liverpool, UK
  LiverpoolUnited Kingdom, United Kingdom
• EncompaSSc site in Groningen, Netherlands
  GroningenNetherlands, Netherlands
• EncompaSSc site in Nowa Sól, Poland
  Nowa SólPoland, Poland
• EncompaSSc site in Bydgoszcz, Poland
  BydgoszczPoland, Poland
• EncompaSSc site in Warszawa, Poland
  WarsawPoland, Poland
• Boston Medical Center
  Boston, MassachusettsUnited States, United States
• Brigham and Women's Hospital
  Boston, MassachusettsUnited States, United States
• EncompaSSc site in Boston, MA
  Boston, MassachusettsUnited States, United States
• EncompaSSc site in Brooklyn, NY
  Brooklyn, New YorkUnited States, United States
• EncompaSSc site in Philadelphia, PA
  Philadelphia, PennsylvaniaUnited States, United States
• Johns Hopkins University
  Baltimore, MarylandUnited States, United States
• EncompaSSc site in Baltimore, MD
  Baltimore, MarylandUnited States, United States
• EncompaSSc site in Sarasota, FL
  Sarasota, FloridaUnited States, United States
• EncompaSSc site in Tampa, FL
  Tampa, FloridaUnited States, United States
• Clinical Research of West Florida
  Tampa, FloridaUnited States, United States
• EncompaSSc site in Clearwater, FL 33765
  Clearwater, FloridaUnited States, United States
• EncompaSSc site in Clearwater, FL 33765
  Clearwater, FloridaUnited States, United States
• Clinical Research of West Florida
  Clearwater, FloridaUnited States, United States
• EncompaSSc site in Pittsburgh, PA
  Pittsburgh, PennsylvaniaUnited States, United States
• EncompaSSc site in Cleveland, OH
  Cleveland, OhioUnited States, United States
• EncompaSSc site in Houston, TX
  Houston, TexasUnited States, United States
• Stryde Research - DFW
  Allen, TexasUnited States, United States
• EncompaSSc site in Dallas, TX
  Dallas, TexasUnited States, United States
• Baylor Scott & White Research Institute
  Dallas, TexasUnited States, United States
• EncompaSSc site in Kansas City, KS
  Kansas City, KansasUnited States, United States
• EncompaSSc site in Minneapolis, MN
  Minneapolis, MinnesotaUnited States, United States
• EncompaSSc site in Oklahoma City, OK
  Oklahoma City, OklahomaUnited States, United States
• University of Colorado Center for Lungs/Breathing/Scleroderma Clinic
  Aurora, ColoradoUnited States, United States
• EncompaSSc site in Phoenix, AZ
  Phoenix, ArizonaUnited States, United States
• EncompaSSc site in La Jolla, CA
  La Jolla, CaliforniaUnited States, United States
• EncompaSSc site in Loma Linda, CA
  Loma Linda, CaliforniaUnited States, United States
• EncompaSSc site in Newport Beach, CA 92663
  Newport Beach, CaliforniaUnited States, United States
• NewportNativeMD, Inc.
  Newport Beach, CaliforniaUnited States, United States
• EncompaSSc site in Newport Beach, CA 92663
  Newport Beach, CaliforniaUnited States, United States
• University of California Los Angeles Scleroderma Center
  Los Angeles, CaliforniaUnited States, United States
• EncompaSSc site in Palo Alto, CA
  Palo Alto, CaliforniaUnited States, United States
• Austin Health
  Heidelberg, VictoriaAustralia, Australia
• Veracity Clinical Research
  Woolloongabba, QueenslandAustralia, Australia
• Griffith University
  Southport, QueenslandAustralia, Australia
• Aotearoa Clinical Trials
  AucklandNew Zealand, New Zealand
• EncompaSSc site in Hamilton, NZ
  HamiltonNew Zealand, New Zealand

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