A Phase 1/2 study of Imzokitug plus Pumitamig and chemotherapy in advanced Non-Small Cell Lung Cancer

Recruiting Phase 2 NCT07680764

Study Description

A clinical trial testing whether adding a new medicine (Imzokitug) to an existing immunotherapy (Pumitamig) and standard chemotherapy works better and is safe enough for patients newly diagnosed with advanced or metastatic lung cancer that has spread

Study Details

Registry ID:: NCT07680764
Conditions:: Locally Advanced Non-Small Cell Lung Cancer (NSCLC), Metastatic Non-Small Cell Lung Cancer (NSCLC)
Phase:: Phase 2
Target Enrollment:: 160 participants
Start Date:: September 10, 2026
Age Range:: 18–999 years
Healthy Volunteers:: No

Study Locations (111 sites)

Local Institution - 0003
Natal/RN, Rio Grande do NorteBrazil, Brazil
Local Institution - 0042
HaileGermany, Germany
Christliches Klinikum Halle (Saale) GmbH
HaileGermany, Germany
Local Institution - 0020
MálagaSpain, Spain
Hospital Carlos Haya De Malaga
MálagaSpain, Spain
Local Institution - 0162
Seville, SevilleSpain, Spain
Local Institution - 0128
Misterbianco, CataniaItaly, Italy
Humanitas Istituto Clinico Catanese
Misterbianco, CataniaItaly, Italy
Local Institution - 0010
MajadahondaSpain, Spain
Local Institution - 0027
BarcelonaSpain, Spain
Local Institution - 0068
BarcelonaSpain, Spain
Local Institution - 0163
BarcelonaSpain, Spain
Hospital Universitari Vall D'Hebron
BarcelonaSpain, Spain
Hospital de la Santa Creu i Sant Pau
BarcelonaSpain, Spain
Local Institution - 0132
Badalona, BarcelonaSpain, Spain
Local Institution - 0110
Marseille, Bouches-du-RhôneFrance, France
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
MarseilleFrance, France
Local Institution - 0087
Montpellier, Languedoc-RoussillonFrance, France
Hôpital Arnaud de Villeneuve - CHU Montpellier
Montpellier, HéraultFrance, France
Local Institution - 0131
Nice, Alpes-MaritimesFrance, France
Local Institution - 0043
BariItaly, Italy
Local Institution - 0159
MilanItaly, Italy
Local Institution - 0047
GrenobleFrance, France
Local Institution - 0014
RavennaItaly, Italy
Local Institution - 0011
Rozzano (MI)Italy, Italy
Local Institution - 0148
BergamoItaly, Italy
Local Institution - 0148
Bergamo, BGItaly, Italy
Local Institution - 0085
Saint-HerblainFrance, France
Local Institution - 0119
Villejuif, Val-de-MarneFrance, France
Local Institution - 0109
ParisFrance, France
Local Institution - 0019
Paris, Île-de-France RegionFrance, France
Hopitaux Universitaires Paris Centre-Hopital Cochin
ParisFrance, France
Local Institution - 0126
Stuttgart, Baden-WurttembergGermany, Germany
Robert Bosch Krankenhaus
Stuttgart, Baden-WurttembergGermany, Germany
Local Institution - 0152
Homburg, SaarlandGermany, Germany
Local Institution - 0075
CraiovaRomania, Romania
Centrul de Oncologie Sf. Nectarie SRL
CraiovaRomania, Romania
Local Institution - 0113
Timișoara, Timiș CountyRomania, Romania
Oncohelp
TimisoaraRomania, Romania
Local Institution - 0037
GuildfordUnited Kingdom, United Kingdom
The Royal Surrey County Hospital NHS Foundation Trust
GuildfordUnited Kingdom, United Kingdom
Local Institution - 0065
CologneGermany, Germany
Klinikum Köln-Merheim
CologneGermany, Germany
Local Institution - 0035
London, Greater LondonUnited Kingdom, United Kingdom
Local Institution - 0076
BucharestRomania, Romania
Institutul Oncologic "Prof. Dr. Alexandru Trestioreanu" Bucuresti (IOB)
BucharestRomania, Romania
Local Institution - 0156
Marburg, HesseGermany, Germany
Local Institution - 0001
São PauloBrazil, Brazil
Local Institution - 0114
FloreștiRomania, Romania
Amethyst Radiotherapy Center-Oncologie Medicala
FloreștiRomania, Romania
Local Institution - 0008
Cluj-NapocaRomania, Romania
Institutul Oncologic Cluj
Cluj-NapocaRomania, Romania
Local Institution - 0182
Birmingham, West MidlandsUnited Kingdom, United Kingdom
Local Institution - 0182
Birmingham, BIRUnited Kingdom, United Kingdom
Local Institution - 0005
Barretos, São PauloBrazil, Brazil
Christliches Klinikum Halle (Saale) GmbH
HalleGermany, Germany
Local Institution - 0125
HessenGermany, Germany
Universitatsklinikum Frankfurt
HessenGermany, Germany
Local Institution - 0115
IașiRomania, Romania
Local Institution - 0116
IașiRomania, Romania
Victoria Hospital (Centrul de oncologie Euroclinic SRL) (Centrul De Oncologie Medicala) (Euroclinic Onchology Center)
IașiRomania, Romania
Institutul Regional de Oncologie Iasi
IașiRomania, Romania
Local Institution - 0006
Porto Alegre, Rio Grande do SulBrazil, Brazil
Local Institution - 0094
Buenos AiresArgentina, Argentina
Instituto Medico Especializado Alexander Fleming
Buenos AiresArgentina, Argentina
Local Institution - 0082
Rosario, Santa Fe ProvinceArgentina, Argentina
Sanatorio Parque Rosario
Rosario, Santa Fe ProvinceArgentina, Argentina
Local Institution - 0092
Viedma, Río Negro ProvinceArgentina, Argentina
Local Institution - 0092
ViedmaArgentina, Argentina
Clinica Viedma S.A.
ViedmaArgentina, Argentina
Local Institution - 0081
Santiago, Santiago MetropolitanChile, Chile
Local Institution - 0149
Santiago, Santiago MetropolitanChile, Chile
Orlandi Oncologia
Santiago, Santiago MetropolitanChile, Chile
Bradfordhill
Santiago, Santiago MetropolitanChile, Chile
Local Institution - 0084
Viña del Mar, ValparaisoChile, Chile
Oncocentro Apys
Viña del Mar, ValparaisoChile, Chile
Local Institution - 0080
New York, New YorkUnited States, United States
Local Institution - 0123
Baltimore, MarylandUnited States, United States
Local Institution - 0183
Washington D.C., District of ColumbiaUnited States, United States
Local Institution - 0170
Athens, GeorgiaUnited States, United States
University Cancer & Blood Center, LLC
Athens, GeorgiaUnited States, United States
Local Institution - 0176
Columbus, OhioUnited States, United States
Local Institution - 0034
Lexington, KentuckyUnited States, United States
Local Institution - 0171
Lexington, KentuckyUnited States, United States
Baptist Health Lexington
Lexington, KentuckyUnited States, United States
Baptist Health Hamburg
Lexington, KentuckyUnited States, United States
Local Institution - 0105
Nashville, TennesseeUnited States, United States
Local Institution - 0180
Hattiesburg, MississippiUnited States, United States
Hattiesburg Clinic
Hattiesburg, MississippiUnited States, United States
Local Institution - 0135
Madison, WisconsinUnited States, United States
Local Institution - 0095
Houston, TexasUnited States, United States
Local Institution - 0102
Omaha, NebraskaUnited States, United States
Oncology Hematology West PC
Omaha, NebraskaUnited States, United States
Nebraska Cancer Specialists
Grand Island, NebraskaUnited States, United States
Local Institution - 0144
Chengdu, SichuanChina, China
Local Institution - 0050
Wuhan, HubeiChina, China
Local Institution - 0048
Perth, Western AustraliaAustralia, Australia
St. John of God Murdoch Hospital
Perth, Western AustraliaAustralia, Australia
Local Institution - 0138
Fuzhou, FujianChina, China
Local Institution - 0147
Nanjing, JiangsuChina, China
Local Institution - 0038
Beijing, Beijing MunicipalityChina, China
Local Institution - 0139
Hangzhou, ZhejiangChina, China
Local Institution - 0137
Hangzhou, ZhejiangChina, China
Local Institution - 0168
Hangzhou, ZhejiangChina, China
Local Institution - 0140
Shanghai, Shanghai MunicipalityChina, China
Local Institution - 0169
Shanghai, Shanghai MunicipalityChina, China
Local Institution - 0100
Heidelberg, VictoriaAustralia, Australia
Local Institution - 0134
Westmead, New South WalesAustralia, Australia
Local Institution - 0074
Gosford, New South WalesAustralia, Australia
Gosford Hospital
Gosford, New South WalesAustralia, Australia
Local Institution - 0167
Greenslopes, QueenslandAustralia, Australia

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